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WUHAN 2.0 ?

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steve(ill) View Drop Down
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Joined: 11 Sep 2009
Location: illinois
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    Posted: 02 Jul 2020 at 9:31pm
(CNN)A global study has found strong evidence that a new form of the coronavirus has spread from Europe to the US. The new mutation makes the virus more likely to infect people but does not seem to make them any sicker than earlier variations of the virus, an international team of researchers reported Thursday.
"It is now the dominant form infecting people," Erica Ollmann Saphire of the La Jolla Institute for Immunology and the Coronavirus Immunotherapy Consortium, who worked on the study, told CNN.
"This is now the virus."
The study, published in the journal Cell, builds on some earlier work the team did that was released on a preprint server earlier in the year. Shared information on genetic sequences had indicated that a certain mutant version of the virus was taking over.
    Now the team has not only checked more genetic sequences, but they have also run experiments involving people, animals and cells in lab dishes that show the mutated version is more common and that it's more infectious than other versions.
    "We do know that the new virus is fitter. It doesn't look at first glance as if it is worse," Saphire said.
    The mutation affects the spike protein -- the structure the virus uses to get into the cells it infects. Now the researchers are checking to see whether this affects whether the virus can be controlled by a vaccine. Current vaccines being tested mostly target the spike protein, but they were made using older strains of the virus.

    Three to nine times more infectious

    The new version seems to multiply faster in the upper respiratory tract -- the nose, sinuses and throat -- which would explain why it passes around more easily, the researchers said.
    But tests on 1,000 hospitalized coronavirus patients in Britain showed those infected with the new version did not fare any worse than those who caught the original strain.
    David Montefiore of Duke University and colleagues tested the virus in the lab. "We were able to test whether the G form of the virus was more infectious than the D form," Montefiore, director of the Laboratory for AIDS Vaccine Research and Development, told CNN.
    "All the results agreed that the G form was three to nine times more infectious than the D form," he added. "We now had experimental evidence that supported, in part, what Bette was seeing in her analysis of the sequences across the globe -- the G form had a fitness advantage in terms of infectivity."


    Edited by steve(ill) - 02 Jul 2020 at 9:34pm
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